Let us assume, for instance, that the gray area on the graph is 30 square centimeters, the pink area is 70 square centimeters, and the total volume expired is 500 milliliters.Dead space (physiology) - Blood gas, acid base, gas exchange terms PaO2 Arterial oxygen tension, or partial pressure PAO2 Alveolar oxygen tension, or partial pressure PACO2 Arterial carbon dioxide tension, or partial pressure PaCO2 Alveolar carbon dioxide tension, or… … Wikipedia Gray area x VE Pink area + Gray area where VD is dead space air and VE is the total volume of expired air. For exact quantification, the following equation is used: With a little thought, the student can see that the gray area represents the air that has no nitrogen in it this area is a measure of the volume of dead space air. Therefore, the recorded nitrogen concentration reaches a plateau level equal to its concentration in the alveoli, as shown to the right in the figure. After still more air has been expired, all the dead space air has been washed from the passages, and only alveolar air remains. Then, when alveolar air begins to reach the nitrogen meter, the nitrogen concentration rises rapidly, because alveolar air containing large amounts of nitrogen begins to mix with the dead space air. Therefore, in the early part of the record, only oxygen appears, and the nitrogen concentration is zero. The first portion of the expired air comes from the dead space regions of the respiratory passageways, where the air has been completely replaced by oxygen. Then the person expires through a rapidly recording nitrogen meter, which makes the record shown in the figure. Some oxygen also mixes with the alveolar air but does not completely replace this air. Rate of Alveolar Ventilation fills the entire dead space with pure oxygen. These problems are discussed further in Chapter 39 in relation to pulmonary gaseous exchange and in Chapter 42 in relation to certain pulmonary diseases. In a normal person, the anatomic and physiologic dead spaces are nearly equal because all alveoli are functional in the normal lung, but in a person with partially functional or nonfunctional alveoli in some parts of the lungs, the physiologic dead space may be as much as 10 times the volume of the anatomic dead space, or 1 to 2 liters. When the alveolar dead space is included in the total measurement of dead space, this is called the physiologic dead space, in contradistinction to the anatomic dead space. On occasion, some of the alveoli themselves are nonfunctional or only partially functional because of absent or poor blood flow through the adjacent pulmonary capillaries.Therefore, from a functional point of view, these alveoli must also be considered dead space. The method just described for measuring the dead space measures the volume of all the space of the respiratory system other than the alveoli and their other closely related gas exchange areas this space is called the anatomic dead space. This record can be used to calculate dead space, as discussed in the text.Īnatomic Versus Physiologic Dead Space. Record of the changes in nitrogen concentration in the expired air after a single previous inspiration of pure oxygen. In making this measurement, the subject suddenly takes a deep breath of oxygen.This Air expired (ml) A simple method for measuring dead space volume is demonstrated by the graph in Figure 37-7. Therefore, the dead space is very disadvantageous for removing the expiratory gases from the lungs. On expiration, the air in the dead space is expired first, before any of the air from the alveoli reaches the atmosphere. This air is called dead space air because it is not useful for gas exchange. Some of the air a person breathes never reaches the gas exchange areas but simply fills respiratory passages where gas exchange does not occur, such as the nose, pharynx, and trachea.